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Ammasi Periasamy, Ph.D.

Professor, Center Director, and Founder of the Keck Center for Cellular Imaging

Biology, University of Virginia
B005 Physical and Life Sciences Building (PLSB), White Head Rd.,
Charlottesville, VA 22904

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Brief Biosketch

- Dr. Periasamy received his M.S. in Physics (Annamalai University), M.S. and Ph.D. degree from Biomedical Engineering, Indian Institute of Technology, Madras, Chennai, India.

- Postdoctoral training at the department of Biomedical Engineering, University Washington, Seattle. Developed a polarization microscopy to investigate muscle fiber contraction. 

- Dr. Periasamy is one of the pioneers in the development of fluorescence lifetime imaging microscopy (FLIM) for measuring the oscillations in cytosolic and nuclear free calcium in single intact living cells. He developed the FLIM system at UNC Chapel Hill. unc flim system


Since 2001, he has been working as a professor of Biology and Biomedical Engineering. Dr. Periasamy is the founder and center director of the internationally known WM Keck Center for Cellular Imaging (KCCI). Dr. Periasamy is an internationally recognized expert in the development of advanced microscopy techniques for single cellular imaging and analysis in living cells, tissue, and animals. A key area of Dr. Periasamy’s research is focused on the design and development of optical methodologies to investigate/monitor exogenous and endogenous molecular interactions. His group has recently developed a FLIRR (Fluorescence Lifetime Redox Ratio) to investigate metabolism and mitochondrial dysfunction in cancer cells and tissues. The main goal of the project is to monitor the early detection of prostate cancer (PCa) and correlate with PSA. The clinical sample tests were encouraging.

His group has developed a 2- and 3-color steady state, confocal, multiphoton, and FLIM based Förster resonance energy transfer (FRET) imaging systems for protein localization in living specimens. He has published more than 185 articles in refereed journals, book chapters and proceedings. He has more than 200 invited lectures nationally and internationally. Dr. Periasamy has edited three books, series book editor on cellular and clinical imaging (11 books), Chairperson in organizing an annual international conference on Multiphoton Microscopy in the Biomedical Sciences through SPIE (since 2001) and runs a hands-on training annual workshop on FLIM, FRET and metabolic imaging Microscopy at the University of Virginia, Charlottesville, during March (since 2002). Dr. Periasamy was elected “Fellow” member of the SPIE Optical Society in 2012.


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